All are true regarding kaposi sarcoma except one ?
**Core Concept**
Kaposi sarcoma (KS) is a type of cancer that forms in the lining of blood and lymph vessels. It is characterized by the proliferation of spindle-shaped cells, which are thought to arise from lymphatic endothelial cells. KS is often associated with human herpesvirus 8 (HHV-8) infection.
**Why the Correct Answer is Right**
Kaposi sarcoma typically presents as skin lesions, which can range from purple macules to nodules or plaques. The lesions may be asymptomatic or painful. In immunocompromised individuals, such as those with HIV/AIDS, KS can progress rapidly and involve multiple organs, including the lymph nodes, lungs, and gastrointestinal tract. The tumor cells in KS express vascular markers, such as CD31 and CD34, and are often positive for HHV-8.
**Why Each Wrong Option is Incorrect**
**Option A:** KS is typically associated with HHV-8 infection. **Option B:** KS can involve multiple organs, including the lymph nodes, lungs, and gastrointestinal tract. **Option C:** KS is characterized by the proliferation of spindle-shaped cells, which are thought to arise from lymphatic endothelial cells.
**Clinical Pearl / High-Yield Fact**
KS is a classic example of a cancer that is associated with a viral infection, and it often presents in immunocompromised individuals. This highlights the importance of considering the patient's immune status when evaluating skin lesions or other symptoms.
**Correct Answer:** B.