All are true regarding DIC, EXCEPT:
## Core Concept
Disseminated Intravascular Coagulation (DIC) is a complex condition characterized by both widespread clotting and bleeding in the vascular system, resulting from an imbalance in the coagulation and anticoagulation mechanisms. It is often associated with underlying critical illnesses such as sepsis, trauma, or malignancy. The condition leads to the consumption of platelets and coagulation factors, causing a paradoxical increase in bleeding tendency.
## Why the Correct Answer is Right
The correct answer, ., implies that the statement regarding DIC is false. Typically, in DIC, there is a decrease in fibrinogen levels due to its consumption during the formation of numerous clots throughout the body. This decrease in fibrinogen, along with the consumption of other clotting factors and platelets, contributes to the bleeding manifestations of DIC.
## Why Each Wrong Option is Incorrect
- **Option A:** Typically, in DIC, there is indeed a decrease in platelet count (thrombocytopenia) due to platelet consumption in the formation of microthrombi. Therefore, stating that thrombocytopenia occurs in DIC is correct.
- **Option B:** Prolongation of coagulation tests (such as PT and aPTT) is a common finding in DIC because of the consumption of clotting factors. This statement is true for DIC.
- **Option C:** Fibrin degradation products (FDPs) are indeed elevated in DIC. As the body tries to dissolve the widespread clots, plasmin breaks down fibrin into FDPs, which can be detected in the blood. This statement is correct.
- **Option D:** Typically, in DIC, fibrinogen levels are decreased, not increased, due to its consumption.
## Clinical Pearl / High-Yield Fact
A key clinical pearl in DIC is that the diagnosis is primarily made based on clinical context (such as the presence of an underlying condition known to cause DIC) and laboratory findings, including thrombocytopenia, prolonged PT and aPTT, decreased fibrinogen, and elevated FDPs. Early recognition and treatment of the underlying cause, along with supportive care, are crucial.
## Correct Answer: D. Increased fibrinogen levels.