All are true regarding chloroquine, EXCEPT :
**Core Concept**
Chloroquine is a 4-aminoquinoline antimalarial drug used for treating and preventing malaria, particularly Plasmodium vivax and Plasmodium ovale. Its mechanism of action involves interfering with hemoglobin digestion in the parasite, leading to the accumulation of toxic heme.
**Why the Correct Answer is Right**
Chloroquine acts by increasing the pH of the lysosome, where heme is produced, making it difficult for the parasite to digest hemoglobin. This results in the accumulation of toxic heme, which ultimately leads to the death of the parasite. Chloroquine also has immunomodulatory effects, which may contribute to its antimalarial activity.
**Why Each Wrong Option is Incorrect**
**Option A:**
*No information provided*
**Option B:**
*No information provided*
**Option C:**
*No information provided*
**Clinical Pearl / High-Yield Fact**
Chloroquine can cause retinal toxicity, particularly at high doses, which can lead to visual disturbances and even blindness. This is a significant side effect that clinicians should be aware of when prescribing chloroquine.
**Correct Answer:** A, B, C
*Note: The question asks for the option that is NOT true, so the correct answer is actually the one that is correct about chloroquine, and the question stem should be rewritten to reflect this.*