All are true of Verner Morrison syndrome (WDHA syndrome) except
**Core Concept**
Verner Morrison syndrome, also known as WDHA syndrome, is a rare condition characterized by excessive secretion of vasoactive intestinal peptide (VIP) leading to a constellation of symptoms. The condition is named after the first two reported cases by Verner and Morrison in 1958. The syndrome is associated with a variety of symptoms including watery diarrhea, hypokalemia, and achlorhydria.
**Why the Correct Answer is Right**
WDHA syndrome is caused by an excessive secretion of VIP, a hormone that stimulates the secretion of water and electrolytes in the gut. The increased VIP levels lead to a significant increase in the secretion of water and chloride ions into the gut lumen, resulting in watery diarrhea. The increased secretion of VIP also leads to hypokalemia due to the loss of potassium ions in the stool. Additionally, the increased secretion of VIP leads to achlorhydria, or a reduction in gastric acid secretion.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because WDHA syndrome is not associated with an increase in gastrin levels. Gastrin is a hormone that stimulates the secretion of gastric acid, and an increase in gastrin levels would lead to an increase in gastric acid secretion, not a decrease.
**Option B:** This option is incorrect because WDHA syndrome is not associated with an increase in insulin levels. An increase in insulin levels would lead to hypoglycemia, not a decrease in blood glucose levels.
**Option C:** This option is incorrect because WDHA syndrome is not associated with an increase in aldosterone levels. Aldosterone is a hormone that regulates electrolyte balance in the body, and an increase in aldosterone levels would lead to an increase in sodium reabsorption and potassium excretion, not a decrease in potassium levels.
**Clinical Pearl / High-Yield Fact**
WDHA syndrome is a rare but important condition to recognize, as it can be associated with a variety of other symptoms including abdominal pain, weight loss, and electrolyte imbalances. A high index of suspicion is necessary to diagnose this condition, as the symptoms can be non-specific and may mimic other conditions.
**Correct Answer: A.**