All are true of septic shock, except: MP 11; Bihar 12; KCET 13
## **Core Concept**
Septic shock is a severe medical condition that occurs when sepsis, which is the body's response to an infection, leads to life-threatening low blood pressure. If not promptly treated, septic shock can lead to inadequate blood flow to vital organs, resulting in organ failure and death. The management of septic shock involves fluid resuscitation, vasopressor support, and antibiotics.
## **Why the Correct Answer is Right**
The correct answer, , implies that a statement regarding septic shock is not true. Typically, in septic shock, there's a decrease in systemic vascular resistance due to the release of various inflammatory mediators. This leads to hypotension. The statement that is not true regarding septic shock needs to be identified among the options.
## **Why Each Wrong Option is Incorrect**
- **Option A:** Typically, patients with septic shock exhibit **hypotension** (low blood pressure) despite adequate fluid resuscitation. Therefore, if an option states something contrary to this fundamental aspect, it would be incorrect.
- **Option B:** Septic shock often presents with **increased cardiac output** initially, as part of the hyperdynamic phase, alongside decreased systemic vascular resistance. So, statements suggesting otherwise might be misleading or incorrect in the context of early septic shock.
- **Option C:** **Vasodilation** is a hallmark of septic shock due to the release of inflammatory mediators. This leads to a decrease in systemic vascular resistance. Therefore, any statement opposing this would be incorrect.
- **Option D:** If is the correct answer, then the explanations for A, B, and C would justify why they are incorrect based on the principles of septic shock.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that **early recognition and intervention** in septic shock are crucial. The Surviving Sepsis Campaign guidelines emphasize the importance of administering fluids and vasopressors to maintain a mean arterial pressure (MAP) of 65 mmHg or higher and to ensure adequate perfusion of vital organs.
## **Correct Answer: D. Decreased cardiac output**