All are true of OPC poisoning, except: AIIMS 13
**Core Concept**
Organophosphate compound (OPC) poisoning is a medical emergency caused by the inhibition of acetylcholinesterase, an enzyme responsible for breaking down acetylcholine in the nervous system. This leads to an accumulation of acetylcholine, resulting in overstimulation of nicotinic and muscarinic receptors.
**Why the Correct Answer is Right**
The correct answer will be an option that is not a characteristic of OPC poisoning. OPC poisoning is characterized by excessive cholinergic activity, leading to symptoms such as bradycardia, salivation, lacrimation, urination, and defecation. The inhibition of acetylcholinesterase also results in the accumulation of acetylcholine at the neuromuscular junction, causing muscle weakness and paralysis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because OPC poisoning is indeed associated with increased salivation, lacrimation, and urination due to the overstimulation of muscarinic receptors.
**Option B:** This option is incorrect because OPC poisoning is characterized by muscle weakness and paralysis due to the accumulation of acetylcholine at the neuromuscular junction.
**Option C:** This option is incorrect because OPC poisoning is associated with bradycardia, not tachycardia. The excessive cholinergic activity leads to a decrease in heart rate.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that OPC poisoning is a medical emergency requiring immediate treatment with atropine and pralidoxime to reverse the effects of acetylcholinesterase inhibition.
**Correct Answer:** D