**Question:** All are true about Rota virus except -

A. Rota virus is a large, non-enveloped, double-stranded RNA virus
B. Rota virus infects only mature lymphocytes
C. Rota virus is sensitive to disinfectants
D. Rota virus cannot cause disease in immunocompetent individuals

**Core Concept:**
Rota virus is a common cause of severe acute gastroenteritis in infants and young children, and is a leading cause of dehydration and hospitalization worldwide. Rota virus infections affect the gastrointestinal tract and lead to symptoms like vomiting, diarrhea, and dehydration.

**Why the Correct Answer is Right:**
D. Rota virus cannot cause disease in immunocompetent individuals - This is incorrect because Rota virus can cause disease in immunocompetent individuals as well. Although the severity of symptoms may be milder in immunocompetent adults, they can still become infected and transmit the virus to others.

C. Rota virus is sensitive to disinfectants - This is partially correct, as Rota virus can be inactivated by certain disinfectants and environmental conditions (e.g., high temperatures, chlorine-based disinfectants, and ultraviolet light). However, it is not completely resistant to disinfectants and can survive on surfaces for extended periods, contributing to the spread of infection.

A. Rota virus is a large, non-enveloped, double-stranded RNA virus - This statement is accurate, describing the structural characteristics of Rota virus as a non-enveloped, double-stranded RNA virus.

B. Rota virus infects only mature lymphocytes - This is incorrect as Rota virus primarily infects the small intestine and leads to gastrointestinal symptoms, not exclusively affecting mature lymphocytes.

**Why Each Wrong Option is Incorrect:**

**Option B:** Rota virus infects only mature lymphocytes - This is incorrect because Rota virus primarily infects the gastrointestinal tract, particularly the small intestine, leading to gastrointestinal symptoms. Infections in the gut cause diarrhea, vomiting, and dehydration, which can lead to severe illness and dehydration in infants and young children.

**Option C:** Rota virus is sensitive to disinfectants - This is partially correct as Rota virus can be inactivated by certain disinfectants and environmental conditions. However, it is not completely resistant to disinfectants and can survive on surfaces for extended periods, contributing to the spread of infection.

**Option D:** Rota virus infects only mature lymphocytes - This statement is incorrect as mentioned above, Rota virus primarily infects the gastrointestinal tract, not only mature lymphocytes.

**Option A:** Rota virus is a large, non-enveloped, double-stranded RNA virus - This statement is accurate, describing the structural characteristics of Rota virus as a large, non-enveloped, double-stranded RNA virus.

**Core Concept:** Rota virus is a leading cause of severe dehydration and hospitalization in young children, especially in developing countries where access to clean water and sanitation is limited, leading to high morbidity and mortality rates. The virus