All are true about Primary sclerosing cholangitis except
**Primary Sclerosing Cholangitis (PSC)**
**Core Concept**
Primary Sclerosing Cholangitis (PSC) is a chronic, progressive liver disease characterized by inflammation and fibrosis of the intrahepatic and extrahepatic bile ducts, leading to bile duct strictures and ultimately cirrhosis. PSC is often associated with inflammatory bowel disease (IBD), particularly ulcerative colitis.
**Why the Correct Answer is Right**
PSC is a rare disease with a prevalence of approximately 1 in 10,000 people. The exact pathogenesis of PSC is not fully understood, but it is thought to involve a combination of genetic predisposition, immune system dysfunction, and environmental factors. The disease is often diagnosed incidentally during imaging studies for unrelated conditions, and the only curative treatment is liver transplantation.
**Why Each Wrong Option is Incorrect**
**Option A:** This statement is true about PSC, as the disease is often associated with IBD, particularly ulcerative colitis.
**Option B:** This statement is also true about PSC, as the disease is characterized by inflammation and fibrosis of the bile ducts, leading to bile duct strictures and cirrhosis.
**Option C:** This statement is true about PSC, as the disease can lead to cholangiocarcinoma, a type of bile duct cancer.
**Option D:** This statement is false about PSC, as the disease is not typically associated with an increased risk of pancreatic cancer.
**Clinical Pearl / High-Yield Fact**
It is essential to consider PSC in the differential diagnosis of patients with unexplained liver enzyme abnormalities, particularly those with a history of IBD.
**Correct Answer:** D.