All are true about minimal change GN except-
**Minimal Change Glomerulonephritis (GN) Core Concept**
Minimal Change GN is a common cause of nephrotic syndrome in children and adults, characterized by the loss of foot processes of podocytes on electron microscopy. It is often associated with an immune-mediated process, but the exact pathogenesis remains unclear.
**Why the Correct Answer is Right**
Minimal Change GN is typically characterized by the absence of significant proteinuria after corticosteroid treatment, and the condition often responds well to immunosuppressive therapy. The disease is also often associated with the presence of circulating immune complexes and the activation of the complement system. The typical histological finding is the effacement of podocyte foot processes, which can be visualized using electron microscopy.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Minimal Change GN is not typically associated with the presence of crescents in the glomeruli, which are more characteristic of rapidly progressive glomerulonephritis.
**Option B:** This option is incorrect because Minimal Change GN is not typically associated with a significant decrease in renal function, as seen in other forms of glomerulonephritis.
**Option C:** This option is incorrect because Minimal Change GN is not typically associated with the presence of hematuria, which is more characteristic of other forms of glomerulonephritis.
**Clinical Pearl / High-Yield Fact**
Minimal Change GN is often associated with an underlying immune-mediated process, and the condition may be triggered by infections or other environmental factors. Corticosteroids are the first-line treatment for Minimal Change GN, and the condition often responds well to immunosuppressive therapy.
**Correct Answer: D.**