All are true about Krukenberg’s tumor except:
**Core Concept**
Krukenberg's tumor refers to the metastasis of a malignant tumor to the ovary, typically originating from a primary site in the gastrointestinal tract, most commonly the stomach. This phenomenon is characterized by the presence of mucin-producing signet-ring cells in the ovarian stroma.
**Why the Correct Answer is Right**
Krukenberg's tumor is named after Friedrich Ernst Krukenberg, who first described it in 1896. The tumor cells in Krukenberg's tumor are known for their distinctive signet-ring morphology, which results from the accumulation of mucin within the cell cytoplasm. This mucin production is thought to be mediated by the enzyme mucinase, which breaks down and accumulates mucin within the tumor cells. The presence of signet-ring cells in the ovarian stroma is a hallmark of Krukenberg's tumor and aids in its diagnosis.
**Why Each Wrong Option is Incorrect**
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**Clinical Pearl / High-Yield Fact**
Krukenberg's tumor is often associated with a poor prognosis, and the primary tumor site should be aggressively sought out and treated. A high index of suspicion is required for early diagnosis, as the symptoms of Krukenberg's tumor can be non-specific and may mimic other ovarian tumors.
**Correct Answer:** .