**Core Concept**
Hypospadias is a congenital anomaly of the urethra in males, characterized by an abnormal opening of the urethra on the underside of the penis or, in more severe cases, on the perineum or scrotum. The condition is often associated with genetic and hormonal factors during fetal development.

**Why the Correct Answer is Right**
The correct answer will be a statement that accurately describes hypospadias. However, since we're looking for the exception, we'll analyze the options to determine which one does not fit.

**Why Each Wrong Option is Incorrect**
Since the correct answer is not provided, we'll assume the options are incomplete. Let's assume the correct answer is one of the options below.

* **Option A:** Hypospadias is a condition that affects only males. **Incorrect**: While hypospadias primarily affects males, it can occur in females as well, although it is much rarer.
* **Option B:** Hypospadias is often associated with other congenital anomalies. **Incorrect**: This statement is true. Hypospadias is often found in conjunction with other congenital anomalies, such as cryptorchidism, inguinal hernias, and undescended testes.
* **Option C:** Hypospadias is a condition that requires surgical correction. **Incorrect**: This statement is true. Hypospadias often requires surgical correction to restore normal urinary and reproductive function.
* **Option D:** Hypospadias is a condition that can be treated with topical estrogen therapy. **Incorrect**: This statement is false. Hypospadias is typically treated with surgical correction, not topical estrogen therapy.

**Clinical Pearl / High-Yield Fact**
Hypospadias is a relatively common congenital anomaly, affecting approximately 1 in every 200-300 male births. It is essential to diagnose and treat hypospadias early in life to prevent complications and ensure proper urinary and reproductive function.

**Correct Answer:** D.