All are true about histological feature of Kaposi’s sarcoma except
**Core Concept**
Kaposi's sarcoma is a type of cancer that affects the skin and mucous membranes, characterized by the proliferation of atypical endothelial cells and the presence of spindle-shaped cells. It often occurs in immunocompromised individuals, particularly those with HIV/AIDS. Histologically, Kaposi's sarcoma is characterized by a distinctive pattern of cellular arrangement.
**Why the Correct Answer is Right**
Kaposi's sarcoma is characterized by the presence of spindle-shaped cells, which are atypical endothelial cells that exhibit a range of morphological features, including a high nuclear-to-cytoplasmic ratio and pleomorphic nuclei. The tumor cells are often arranged in a characteristic "slit-like" pattern, with a mixture of spindle cells and inflammatory cells. This histological pattern is diagnostic of Kaposi's sarcoma.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe a histological feature of Kaposi's sarcoma. While the tumor cells may exhibit a range of morphological features, they are not typically described as having a "high mitotic rate".
**Option B:** This option is incorrect because it is not a specific histological feature of Kaposi's sarcoma. While the tumor cells may exhibit a range of immunophenotypic features, they are not typically described as being "CD30-positive".
**Option C:** This option is incorrect because it does not accurately describe a histological feature of Kaposi's sarcoma. While the tumor cells may exhibit a range of morphological features, they are not typically described as having a "foamy appearance".
**Clinical Pearl / High-Yield Fact**
Kaposi's sarcoma is a classic example of a tumor that is associated with immunocompromise, and its histological features are often characteristic of a tumor that has arisen in the setting of impaired immune surveillance.
**Correct Answer: A.**