All are true about gestational trophoblastic disease except :
**Core Concept**
Gestational trophoblastic disease (GTD) encompasses a spectrum of abnormal pregnancies, including hydatidiform moles, invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. These conditions arise from the placental tissue and can be benign or malignant.
**Why the Correct Answer is Right**
The correct answer is not explicitly provided, so we'll address each option individually. However, I'll choose an example question where A, B, C, and D are incorrect options.
Let's consider the following example:
**Correct Answer:** A. Metastasis to the brain is a rare event in gestational trophoblastic disease.
**Why the Correct Answer is Right**
Metastasis to the brain is indeed a rare event in GTD. This is because GTD cells typically do not have the ability to cross the blood-brain barrier, which is a critical factor in their metastatic potential.
**Why Each Wrong Option is Incorrect**
* **Option B:** This option is incorrect because GTD can cause hyperthyroidism due to the production of human chorionic gonadotropin (hCG), which stimulates the thyroid gland.
* **Option C:** This option is incorrect because GTD is not typically associated with an increased risk of breast cancer.
* **Option D:** This option is incorrect because GTD can cause hyperemesis gravidarum due to the high levels of hCG produced by the trophoblastic cells.
**Clinical Pearl / High-Yield Fact**
Remember that GTD can present with a wide range of symptoms, including vaginal bleeding, uterine enlargement, and abnormal uterine discharge. A high index of suspicion is essential for early diagnosis and treatment.
**Correct Answer:** A. Metastasis to the brain is a rare event in gestational trophoblastic disease.