All are TRUE about diuretic associated hypokalemia, EXCEPT:
Correct Answer: Loop diuretic cause more hypokalemia than thiazide diuretics
Description: Diuretic use is an impoant cause of hypokalemia. Thiazides cause more profound hypokalemia than loop diuretics. MUST KNOW: Mechanisms of hypokalemia in diuretic use: Increases distal tubular Na+ delivery and distal tubular flow rate in addition to secondary hyperaldosteronism. Thiazides have an effect on plasma K+ concentration greater than that of loop diuretics. It is due to thiazide-associated hypocalciuria versus the hypercalciuria seen with loop diuretics. It reduces the lumen-negative potential difference and attenuating distal K+ excretion. ALSO NOTE: High doses of penicillin-related antibiotics (nafcillin, dicloxacillin, ticarcillin, oxacillin, and carbenicillin) can increase K+ excretion. Aminoglycosides, amphotericin, foscarnet, cisplatin, and ifosfamide cause renal K+ and magnesium wasting, leading to hypokalemia and hypomagnesemia Ref: Harrison, Edition-18, page- 352.
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