All are true about Clozapine except

A. More potently blocks D2 as compared to D1 receptors

B. Blood level below 350 ng/ml should be maintained to avoid agranulocytosis

C. Should not be used along with Carbamazepine

D. Should be discontinued if the WBC count is below 3,000/ .' mm cells

Correct Answer: Blood level below 350 ng/ml should be maintained to avoid agranulocytosis

Description: side effects are sedation, unstable BP, tachycardia, urinary incontinence, weight gain and precipitation of diabetes. Few cases of myocarditis have been repoed which sta like flu but may progress to death. Clozapine is used as a reserve drug in resistant schizophrenia. Its mechhanism as follows Ref: KD TRIPATHI 8TH ED.

Category: Pharmacology

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