Medicine All are TRUE about Antineutrophil Cytoplasmic Antibodies, EXCEPT: A Proteinase-3, in neutrophil azurophilic granules, is the major cANCA antigen B The major target for pANCA is the enzyme myeloperoxidase C A pANCA pattern of staining has been associated with nonvasculitic entities such as rheumatic and nonrheumatic autoimmune diseases D There are three major categories of ANCA 💡 Explanation All are TRUE about Antineutrophil Cytoplasmic Antibodies, EXCEPT: ✓ Correct Answer: D. There are three major categories of ANCA