**Question:** All are true about amoebic ulcer except

A. Amoebic ulcers are caused by the ingestion of contaminated food or water.
B. The infection typically affects the small intestine.
C. Antibiotics are a common treatment for amoebic ulcers.
D. Most cases of amoebic ulcers resolve on their own without medical intervention.

**Correct Answer:** D. Most cases of amoebic ulcers resolve on their own without medical intervention.

**Core Concept:** Amoebic ulcers are gastrointestinal lesions caused by the protozoan parasite Entamoeba histolytica. This infection often results from the ingestion of contaminated food or water. The infection primarily affects the large intestine and liver, leading to symptoms such as abdominal pain, diarrhea, fever, and hepatosplenomegaly.

**Why the Correct Answer is Right:** The correct answer (D) is right because amoebic ulcers, while often associated with the ingestion of contaminated food or water, do not generally heal on their own without medical intervention. The infection typically progresses to cause complications like amoebic colitis, liver abscess, and disseminated amoebiasis. Medical intervention is necessary to prevent severe complications and ensure proper treatment.

**Why Each Wrong Option is Incorrect:**

A. Amoebic ulcers are indeed caused by the ingestion of contaminated food or water, making this statement accurate.
B. While amoebic ulcers can involve the small intestine, the correct answer should focus on the large intestine and liver, as these are more commonly affected organs.
C. Antibiotics are used for treating amoebiasis, especially in severe cases, and this statement is incorrect. The appropriate treatment generally includes antiprotozoal drugs like Metronidazole, Tinidazole, or Nitazoxanide, along with supportive care, depending on the severity of the infection.

**Clinical Pearl:** Amoebiasis is a common parasitic infection affecting millions globally, particularly in developing countries. Early diagnosis and appropriate treatment can prevent severe complications and ensure effective management of the infection.