All are true about acetaminophen except:
Correct Answer: About 95% of acetaminophen undergoes detoxification by CYP2E1
Description: At therapeutic doses, about 95% of acetaminophen undergoes detoxification in the liver by phase II enzymes and is excreted in the urine as glucuronate or sulfate conjugates The injury produced by NAPQI (N-acetyl-benzoquinoneimine) involves two mechanisms: Covalent binding to hepatic proteins-Damage to cellular membranes and mitochondrial dysfunction, Depletion of glutathione, making hepatocytes more susceptible to reactive oxygen species-induced injury
Category:
Pathology
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