All are the true regarding hyperophic obstructive cardiomyopathy, except-
Correct Answer: Systolic dysfunction
Description: Ref:Harrison's 19th E pg 1569 It is diastolic dysfunction. At the level of the sarcomere, hyperophic cardiomyopathy mutations lead to enhanced calcium sensitivity, maximal force generation, and ATPase activity. Calcium handling is affected through modification of regulatory proteins. Sarcomere mutations lead to abnormal energetics and impaired relaxation, both directly and as a result of hyperophy.
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