All are seen in VKH syndrome except –
**Core Concept**
Vogt-Koyanagi-Harada (VKH) syndrome is a rare autoimmune disorder characterized by inflammation and damage to multiple organ systems, including the eyes, skin, and central nervous system. The condition is associated with a complex interplay of immune cells and inflammatory mediators that target melanin-containing cells and tissues.
**Why the Correct Answer is Right**
VKH syndrome typically presents with a triad of symptoms: uveitis (inflammation of the uvea in the eye), alopecia (hair loss), and vitiligo (skin depigmentation). The condition is also often associated with poliosis (white patches on the hair), meningeal irritation, and hearing loss. The pathophysiology of VKH involves the activation of T-lymphocytes and the production of autoantibodies against melanin-containing cells, leading to inflammation and tissue damage.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as VKH syndrome is classically associated with uveitis, which is inflammation of the uvea in the eye.
**Option B:** This option is incorrect as VKH syndrome is not typically associated with rheumatoid arthritis, which is an autoimmune disorder that affects the joints.
**Option C:** This option is incorrect as VKH syndrome is not typically associated with Sjögren's syndrome, which is an autoimmune disorder that affects the exocrine glands.
**Option D:** This option is incorrect as VKH syndrome is not typically associated with SLE (Systemic Lupus Erythematosus), which is a complex autoimmune disorder that affects multiple organ systems.
**Clinical Pearl / High-Yield Fact**
VKH syndrome is often referred to as "the great imitator" due to its diverse and nonspecific symptoms, which can mimic other autoimmune and inflammatory disorders. A high index of suspicion is required for diagnosis, and a thorough understanding of the condition's pathophysiology and clinical presentation is essential for accurate diagnosis and management.
**Correct Answer: B. Rheumatoid Arthritis**