All are seen in malignant hypeension except?
Correct Answer: Hyaline aeriolosclerosis
Description: Malignant hypeension, defined as blood pressure usually greater than 200/120 mm Hg, is far less common in the United States than so-called "benign" hypeension and occurs in only about 5% of persons with elevated blood pressure. It may arise de novo (i.e., without preexisting hypeension), or it may appear suddenly in a person who had mild hypeension. Pathogenesis The basis for this turn for the worse in hypeensive subjects is unclear, but the following sequence is suggested: The initialevent seems to be some form of vascular damage to the kidneys. This most commonly results from long-standing hypeension, with eventual injury to the aeriolar walls. The result is increased permeability of the small vessels to fibrinogen and other plasma proteins, endothelial injury, and platelet deposition. This leads to the appearance of fibrinoidnecrosis of aerioles and small aeries and intravascular thrombosis. Mitogenic factors from platelets (e.g., platelet derived growth factor) and plasma cause intimal hyperplasia of vessels, resulting in the hyperplastic aeriolosclerosistypical of organizing injury of malignant hypeension and of morphologically similar thrombotic microangiopathies (seelater) and fuher narrowing of the lumina. The kidneys become markedly ischemic. Robbins Basic pathology,9th edition,pg no.539
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now