All are seen in HUS except –
Correct Answer: Alteredsensorium
Description: Ans. is 'b' i.e., Altered sensorium Essentials of diagnosis of hemolytic uremic syndromeo Microangiopathic hemolytic anemia.o Thrombocytopenia and renal failure (may cause | K+)o Elevated serum LDHNo Normal coagulation tests.o Absence of neurological abnormalities."Hyperkalemia is seen in hemolytic urenic syndrome as a result of renal failure."ABOUT NEUROPSYCHIATRIC MANIFESTATIONSo Neurological manifestations are used to distinguish between Hemolytic uremic syndrome and Thrombotic Thrombocytopenic Purpura.o Both H.U.S. and T.T.P are thrombotic microangiopathy.o Both H.U.S and T.T.P present with thrombocytopenia and microangiopathic hemolytic anemia.o "H.U.S. is distinguished from T.T.P by the Absence of neurological symptoms and the prominence of acute renal failure."o Recent studies, however have tended to blurr these clinical distinctions.o Many adult patients with "T.T.P." lack one or more of the five criteria and patients with "HUS" have fever and neurological dysfunction.
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