**Core Concept**
Whipple's operation, also known as pancreaticoduodenectomy, is a complex surgical procedure used to treat various conditions affecting the pancreas, duodenum, and surrounding tissues. The operation involves the removal of several structures, including the head of the pancreas, the duodenum, the gallbladder, and a portion of the bile duct.

**Why the Correct Answer is Right**
Whipple's operation typically involves the resection of the following structures: the head of the pancreas, the duodenum, the gallbladder, and a portion of the bile duct. The key structures that are resected in this operation are those involved in the digestive process and the drainage of bile from the liver into the intestine.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is not provided, so we can't evaluate it.
**Option B:** This option is not provided, so we can't evaluate it.
**Option C:** This option is not provided, so we can't evaluate it.
**Option D:** This option is not provided, so we can't evaluate it.

**Clinical Pearl / High-Yield Fact**
In Whipple's operation, the preservation of the spleen is often attempted, but the spleen may be sacrificed if it is adherent to the tumor or if there is significant vascular involvement.

**Correct Answer:**
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