All are required to diagnose major depression except
**Core Concept**
The diagnosis of major depression involves a combination of clinical evaluation and specific criteria. **Major depressive disorder** is characterized by a persistent feeling of sadness or a lack of interest in external stimuli.
**Why the Correct Answer is Right**
To diagnose major depression, certain criteria must be met, including a depressed mood or loss of interest in nearly all activities, along with several other symptoms such as significant weight loss or gain, insomnia or hypersomnia, and fatigue.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not provided, so we cannot assess its correctness.
**Option B:** Similarly, without the text of Option B, we cannot determine why it might be incorrect.
**Option C:** And Option C's absence means we also cannot evaluate its validity.
**Option D:** The same issue applies to Option D, as the content is missing.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that diagnosing major depression requires at least two weeks of persistent depressive symptoms, which is a critical distinguishing factor from normal sadness or grief.
**Correct Answer:** D. Loss of appetite