All are reduced in iron deficiency anemia except
Correct Answer: Total iron-binding capacity
Description: ANS. BTotal iron-binding capacity (TIBC) is increased in iron deficiency anemia (IDA), decreased in anemia of chronic diseases.Differential diagnosis of microcytic anemia Iron deficiency anemiaAnemia of chronic diseaseThalassemiaSideroblastic anemiaMCVReducedLow normal or normalLowLow inherited but normal in acquiredSerum ironReducedReducedNormalRaisedSerum TIBCRaisedReducedNormalNormalSerum ferritinReducedNormal or raisedNormalRaisedIron in BMAbsentPresentPresentPresentAbbreviations: MCV, mean corpuscular volume; TIBC, total iron-binding capacity; BM, bone marrowStages of iron deficiency anemia1. Stage of negative iron balance- Serum iron is normal- Serum TIBC increases- Seum ferritin decreases- Bone marrow iron decreases- Percentage transferin saturation is normal2. Stage of iron deficient erythropoiesis- Serum iron decreases- Percentage transferrin saturation decreases3. Stage of microcytic hypochromic anemia- Peripheral smear shows microcytic hypochromic anemia- Serum iron decreases- Percentage transferrin saturation decreases.
Category:
Pathology
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