**Core Concept**
The question tests knowledge of **Celsus' signs of inflammation**, which are classic indicators of the inflammatory process. These signs are fundamental to understanding **pathophysiology** and **clinical presentation** of inflammation.

**Why the Correct Answer is Right**
Since the correct answer is not provided, let's discuss the general concept. Celsus' signs include **redness**, **swelling**, **heat**, and **pain**. These signs are a result of increased **blood flow** and **permeability** due to the release of **inflammatory mediators**.

**Why Each Wrong Option is Incorrect**
**Option A:** Without the correct answer, we cannot directly address each option. Normally, we would explain why each choice does not fit as an exception to Celsus' signs.
**Option B:**
**Option C:**
**Option D:**

**Clinical Pearl / High-Yield Fact**
Remember, Celsus' signs are **redness (rubor)**, **swelling (tumor)**, **heat (calor)**, and **pain (dolor)**. These are key indicators of the inflammatory process, mediated by various **chemical mediators**.

**Correct Answer:** D. Loss of function