**Core Concept**
The treatment of alcohol withdrawal syndrome (AWS) involves managing symptoms such as tremors, agitation, and seizures. The primary goal is to reduce the risk of seizures and delirium tremens. Benzodiazepines (BZDs) have been the mainstay of treatment for AWS due to their effectiveness in reducing anxiety and agitation.

**Why the Correct Answer is Right**
Benzodiazepines, such as chlordiazepoxide and diazepam, work by enhancing the activity of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor. This leads to a decrease in excitatory neurotransmitter release and a subsequent reduction in neuronal activity. The use of BZDs in AWS is supported by evidence from numerous clinical trials, which have consistently shown a significant reduction in the severity and incidence of withdrawal symptoms. Additionally, BZDs have been shown to be effective in reducing the risk of seizures and delirium tremens.

**Why Each Wrong Option is Incorrect**
**Option A:** Beta-blockers, such as propranolol, are used in the treatment of hypertension and certain cardiovascular conditions. They are not effective in managing the symptoms of AWS and can potentially worsen the condition by masking symptoms of withdrawal.

**Option C:** Amitriptyline is a tricyclic antidepressant that is primarily used in the treatment of depression. It is not effective in managing the symptoms of AWS and can potentially worsen the condition by causing sedation and confusion.

**Option D:** Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that are primarily used in the treatment of depression. They are not effective in managing the symptoms of AWS and can potentially worsen the condition by causing anxiety and agitation.

**Clinical Pearl / High-Yield Fact**
It's essential to note that the use of BZDs in AWS should be tapered off gradually to avoid rebound symptoms. A gradual tapering schedule should be used to minimize the risk of withdrawal symptoms and seizures.

**✓ Correct Answer: B. BZD**