After binding of complement and antibody on the surface of encapsulated bacteria, the process of phagocytosis by polymorphonuclear leukocytes/macrophages is enhanced by all of the following opsonins, except?
Correct Answer: CD11b/CD18
Description: The efficiency of phagocytosis is greatly enhanced when microbes are coated with opsonins for which the phagocytes express high-affinity receptors. The major opsonins are immunoglobulin G (IgG) antibodies, the C3b breakdown product of complement, and ceain plasma lectins, notably mannose-binding lectin and collectins, all of which are recognized by specific receptors on leukocytes. CD11b/CD18 (MAC-1) is macrophage integrin which help in binding of microbes to macrophages, and are not opsonins.
Category:
Pathology
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