Affinity of Hemoglobin-F for oxygen is more than Hemoglobin-A for which of the following reason?
Correct Answer: 2,3 DPG poorly binds to fetal HB
Description: Answer: d) 2,3 DPG poorly binds to fetal HB.* Under physiologic conditions, Hb F has a higher affinity for oxygen than does Hb A, as a result of Hb F binding only weakly to 2,3-BPG.* The y-globin chains of Hb F lack some of the positively charged amino acids that are responsible for binding 2,3-BPG in the P-globin chains.* Because 2,3-BPG serves to reduce the affinity of hemoglobin for oxygen, the weaker interaction between 2,3-BPG and Hb-F results in a higher oxygen affinity for Hb F relative to Hb A.* In contrast, if both Hb A and Hb F are stripped of their 2,3-BPG, they then have a similar affinity for oxygen.
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now