**Core Concept**
Growth hormone (GH) therapy is used to treat growth hormone deficiency, Turner syndrome, and other conditions. It stimulates cellular growth and metabolism. However, excessive GH can lead to various adverse effects due to its impact on glucose metabolism, lipid profiles, and bone health.

**Why the Correct Answer is Right**
Growth hormone therapy can cause a range of adverse effects, including glucose intolerance, insulin resistance, and an increased risk of diabetes mellitus. This is because GH counteracts the effects of insulin, leading to hyperglycemia. Additionally, GH can cause an increase in lipid profiles, including low-density lipoprotein (LDL) cholesterol and triglycerides. Furthermore, excessive GH can lead to joint pain, carpal tunnel syndrome, and slipped capital femoral epiphysis due to its effects on bone growth and development.

**Why Each Wrong Option is Incorrect**
**Option A:** While GH can cause an increase in blood pressure, this is not the primary concern with GH therapy.
**Option B:** GH can cause an increase in LDL cholesterol, but this is not the best answer choice.
**Option C:** GH therapy is not typically associated with an increased risk of osteoporosis, as it can actually help improve bone density.

**Clinical Pearl / High-Yield Fact**
GH therapy can have significant effects on glucose metabolism, and patients should be monitored closely for signs of glucose intolerance or diabetes mellitus.

**Correct Answer:** C.