Advantage of desmopressin over vasopressin in the treatment of diabetes insipidus is that desmopressin:
Correct Answer: Is more selective for V2 receptor subtype
Description: Desmopressin is selective agonist of V2 receptors of vasopressin. V2 receptors are present in kidney and on endothelium whereas V1 receptors are present in blood vessels. Therefore, -Desmopressin is less likely to cause vasoconstriction than vasopressin. -Desmopressin has similar risk of causing hyponatremia due to retention of water. -Desmopressin can release of factor VIII and vWF similar to vasopressin. -Both desmopressin and vasopressin can provide similar relief of excessive thirst.
Category:
Pharmacology
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