Chemical process involved in conversion of nor-adrenaline to adrenaline ?
**Core Concept**
The conversion of nor-adrenaline to adrenaline involves a specific biochemical reaction that increases the potency of the catecholamine. This process is crucial for the regulation of the sympathetic nervous system and the body's response to stress.
**Why the Correct Answer is Right**
The conversion of nor-adrenaline to adrenaline is catalyzed by the enzyme phenylethanolamine N-methyltransferase (PNMT). This enzyme specifically methylates the nor-adrenaline molecule at the N-ethyl group, resulting in the formation of adrenaline. This reaction increases the lipophilicity of adrenaline, allowing it to cross the blood-brain barrier and exert its effects on the brain and other tissues.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not specify the enzyme involved in the conversion of nor-adrenaline to adrenaline.
* **Option B:** This option is incorrect because it is not a known enzyme involved in the conversion of nor-adrenaline to adrenaline.
* **Option D:** This option is incorrect because it does not accurately describe the biochemical reaction involved in the conversion of nor-adrenaline to adrenaline.
**Clinical Pearl / High-Yield Fact**
The enzyme PNMT is primarily found in the adrenal medulla, where it plays a critical role in the synthesis of adrenaline. This knowledge is essential for understanding the regulation of the sympathetic nervous system and the body's response to stress.
**Correct Answer: C. Phenylethanolamine N-methyltransferase (PNMT).**