Maximum dose of lignocaine given with adrenaline for infiltration anesthesia is
**Core Concept**
Lignocaine (lidocaine) is a local anesthetic agent that works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses. When used with adrenaline (epinephrine), it prolongs the duration of anesthesia and reduces systemic toxicity. However, the maximum dose of lignocaine with adrenaline is limited by the risk of systemic toxicity, including central nervous system (CNS) and cardiovascular effects.
**Why the Correct Answer is Right**
The maximum dose of lignocaine with adrenaline is 7 mg/kg without a maximum total dose. This is because adrenaline helps to reduce the systemic absorption of lignocaine, thereby reducing the risk of CNS toxicity. The addition of adrenaline also allows for a higher total dose of lignocaine, as it helps to prolong the duration of anesthesia. However, it is essential to note that the maximum dose of lignocaine should not exceed 7 mg/kg, and the total dose should not exceed 500 mg.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify the maximum dose of lignocaine with adrenaline.
**Option B:** This option is incorrect because it does not provide any specific information about the maximum dose of lignocaine with adrenaline.
**Option C:** This option is incorrect because it exceeds the maximum recommended dose of lignocaine with adrenaline.
**Clinical Pearl / High-Yield Fact**
When using lignocaine with adrenaline for infiltration anesthesia, it is essential to remember that the maximum dose is 7 mg/kg without a maximum total dose, and the total dose should not exceed 500 mg. This is to prevent systemic toxicity, including CNS and cardiovascular effects.
**Correct Answer: C. 525 mg.**