**Core Concept**
Amyl nitrite is used in the treatment of cyanide poisoning due to its ability to induce methemoglobinemia, which binds to cyanide and forms a stable complex, effectively reducing the toxic effects of cyanide.
**Why the Correct Answer is Right**
In cyanide poisoning, amyl nitrite is administered via inhalation, which rapidly increases methemoglobin levels in the blood. Methemoglobin has a higher affinity for cyanide than cytochrome c oxidase, the enzyme that is typically inhibited by cyanide. By binding to cyanide, methemoglobin prevents it from inhibiting cellular respiration, thereby reducing the toxic effects of cyanide. This mechanism is crucial in the initial treatment of cyanide poisoning.
**Why Each Wrong Option is Incorrect**
**Option A:**
Intravenous administration of amyl nitrite is not a recommended route due to its rapid metabolism and potential for adverse effects.
**Option B:**
Subcutaneous administration of amyl nitrite is not a standard approach in the treatment of cyanide poisoning.
**Option C:**
Oral administration of amyl nitrite would result in delayed onset of action and reduced efficacy in treating cyanide poisoning.
**Clinical Pearl / High-Yield Fact**
Amyl nitrite is a key component of the cyanide antidote kit, and its use should be initiated promptly in cases of suspected cyanide poisoning.
**Correct Answer: C. Oral administration of amyl nitrite would result in delayed onset of action and reduced efficacy in treating cyanide poisoning.**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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