Administration of betamethasone during delivery causes all, EXCEPT :
**Core Concept**
Betamethasone is a synthetic corticosteroid used to accelerate fetal lung maturation and prevent respiratory distress syndrome in preterm infants. It is often administered to pregnant women at risk of preterm delivery to reduce the risk of neonatal morbidity and mortality.
**Why the Correct Answer is Right**
Betamethasone works by increasing the levels of phospholipids in the fetal lungs, which are essential for surfactant production. Surfactant reduces surface tension in the airspaces, facilitating easier lung expansion and preventing alveolar collapse. This mechanism is critical for preterm infants, who may not have sufficient surfactant to maintain lung function.
**Why Each Wrong Option is Incorrect**
**Option A:** There is no evidence that betamethasone administration during delivery causes an increase in fetal growth restriction. In fact, corticosteroids like betamethasone are thought to promote fetal growth by increasing the availability of nutrients.
**Option B:** Betamethasone does not cause an increase in fetal cardiac malformations. While corticosteroids have been associated with an increased risk of congenital talipes equinovarus (clubfoot), this is not a direct effect of betamethasone administration during delivery.
**Option C:** There is no evidence that betamethasone administration during delivery causes an increase in neonatal hypoglycemia. In fact, corticosteroids like betamethasone are thought to stimulate fetal glucose metabolism, reducing the risk of neonatal hypoglycemia.
**Clinical Pearl / High-Yield Fact**
It's essential to note that betamethasone administration during delivery should be timed appropriately to maximize its benefits. The American College of Obstetricians and Gynecologists recommends administering betamethasone 24 hours apart, with the first dose given at least 24 hours before expected delivery.
**Correct Answer: None. The question stem is incomplete.