Which of the following antibiotic can be administered in group B B lactamase induced resistance?
**Core Concept**
Beta-lactamase is an enzyme produced by certain bacteria that confers resistance to beta-lactam antibiotics, which include penicillins and cephalosporins. Beta-lactamase induction occurs when bacteria are exposed to a beta-lactam antibiotic, leading to the production of the enzyme, which inactivates the antibiotic.
**Why the Correct Answer is Right**
Aminoglycosides are a class of antibiotics that are not affected by beta-lactamase enzymes. They work by binding to the bacterial 30S ribosomal subunit and inhibiting protein synthesis. Aminoglycosides can be used to treat infections caused by bacteria that have developed resistance to beta-lactam antibiotics through beta-lactamase production. Examples of aminoglycosides include gentamicin and tobramycin.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because beta-lactam antibiotics, such as penicillin, are inactivated by beta-lactamase enzymes and would not be effective against beta-lactamase-producing bacteria.
**Option B:** This option is incorrect because fluoroquinolones, such as ciprofloxacin, are a class of antibiotics that inhibit DNA replication and are not affected by beta-lactamase enzymes, but they are not the first choice in this scenario.
**Option C:** This option is incorrect because macrolides, such as erythromycin, inhibit protein synthesis by binding to the bacterial 50S ribosomal subunit, but they are not the best choice in this scenario.
**Clinical Pearl / High-Yield Fact**
Aminoglycosides can cause nephrotoxicity and ototoxicity, so their use should be limited to severe infections and closely monitored.
**Correct Answer:** C. Aminoglycosides