Addisons’s disease is associated with all except –
**Core Concept**
Addison's disease is a rare endocrine disorder characterized by the inadequate production of cortisol and, in some cases, aldosterone hormones. This condition occurs due to the destruction of the adrenal cortex, which impairs the synthesis of these crucial hormones.
**Why the Correct Answer is Right**
The adrenal cortex produces cortisol, a vital hormone that regulates metabolism, immune response, and stress response. Aldosterone, another hormone produced by the adrenal cortex, plays a crucial role in maintaining electrolyte balance and blood pressure. In Addison's disease, the destruction of the adrenal cortex leads to a deficiency of these hormones, resulting in symptoms such as fatigue, weight loss, and hypotension.
**Why Each Wrong Option is Incorrect**
**Option A:** While hypoglycemia is not a direct consequence of Addison's disease, it can be a complication due to the impaired production of cortisol, which affects glucose metabolism. However, this is not the most accurate association.
**Option B:** Hyperkalemia is indeed associated with Addison's disease, particularly with primary adrenal insufficiency, as the impaired production of aldosterone leads to increased potassium levels.
**Option C:** Hypocalcemia is not directly associated with Addison's disease. While there may be some electrolyte imbalances, hypocalcemia is not a characteristic feature of this condition.
**Option D:** Hypernatremia is not directly associated with Addison's disease. In fact, hypotension and hyponatremia are more common due to the impaired production of aldosterone, leading to increased sodium excretion.
**Clinical Pearl / High-Yield Fact**
In patients with Addison's disease, the administration of glucocorticoids can lead to a rapid increase in blood pressure, highlighting the importance of monitoring blood pressure in these patients.
**Correct Answer: A. Hypoglycemia**