ADCC is seen with which of the following cells
**Core Concept**
Antibody-dependent cellular cytotoxicity (ADCC) is a mechanism of immune response that involves the activation of immune cells to destroy target cells. It is mediated by Fc receptors on the surface of immune cells, which recognize and bind to the Fc region of antibodies.
**Why the Correct Answer is Right**
ADCC occurs when a target cell is bound by an antibody, and the Fc region of the antibody is recognized by an Fc receptor on the surface of an immune cell, such as a natural killer (NK) cell or a macrophage. This binding of the antibody to the Fc receptor activates the immune cell, leading to the release of cytotoxic granules that destroy the target cell. In this process, the Fc receptor on the immune cell plays a crucial role in recognizing and binding to the Fc region of the antibody.
**Why Each Wrong Option is Incorrect**
* **Option A:** This is not a correct option, as the specific cell type involved in ADCC is not provided. However, if this option were a specific cell type, it would likely be incorrect because ADCC is not a characteristic of this cell type.
* **Option B:** This option is incorrect because ADCC is not typically associated with T cells, which are primarily involved in cell-mediated immunity.
* **Option C:** This option is incorrect because while some dendritic cells can express Fc receptors, they are not the primary cells involved in ADCC.
**Clinical Pearl / High-Yield Fact**
ADCC is an important mechanism of immune response that helps to eliminate infected cells or tumor cells. Understanding the role of Fc receptors and the process of ADCC is crucial for developing effective immunotherapies.
**Correct Answer:** C. Macrophages are one of the key cells involved in ADCC, although other cells like NK cells can also participate in this process.