Active metabolite of carisoprodol is:
**Core Concept**
Carisoprodol is a centrally acting muscle relaxant metabolized via hepatic cytochrome P450 enzymes. Its active metabolite contributes to therapeutic effects by modulating GABAergic neurotransmission.
**Why the Correct Answer is Right**
The active metabolite of carisoprodol is **meprobamate**, which acts as a GABAergic enhancer. It binds to GABAA receptors, increasing chloride ion influx and neuronal inhibition. Meprobamate is responsible for the drug's sedative, anxiolytic, and muscle-relaxant properties.
**Why Each Wrong Option is Incorrect**
**Option A:** *Succinimide derivatives* (e.g., mephobarbital) are inactive metabolites with no pharmacological activity.
**Option B:** *Cyclohexyl derivatives* (e.g., carisoprodol’s parent structure) are the prodrug form; they lack intrinsic activity.
**Option D:** *Hydroxylated metabolites* (e.g., 5-hydroxy carisoprodol) are inactive and excreted unchanged in urine.
**Clinical Pearl / High-Yield Fact**
Remember: **"Carisoprodol → Meprobamate"**. Meprobamate’s GABAergic activity explains its therapeutic and abuse potential. Avoid co-administration with benzodiazepines due to additive CNS depression.
**Correct Answer: C. Meprobamate**