Pathway activated on contact with glass test tube by itself is termed ?
**Core Concept**
The question is testing the student's knowledge of contact activation of coagulation factors. Contact activation occurs when blood comes into contact with a non-endothelial surface, such as glass, and leads to the activation of the intrinsic coagulation pathway.
**Why the Correct Answer is Right**
When blood comes into contact with a glass test tube, the intrinsic pathway is activated through the contact activation of factor XII (Hageman factor). This leads to the activation of factor XI, which in turn activates factor IX and factor X, ultimately resulting in the formation of thrombin and fibrin. The intrinsic pathway is crucial for the regulation of blood coagulation in response to trauma or injury.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect as it does not directly relate to the contact activation of coagulation factors.
* **Option B:** This option is incorrect as it refers to the extrinsic pathway, which is activated by tissue factor, not contact with glass.
* **Option C:** This option is incorrect as it refers to the common pathway, which is the final common pathway of coagulation, but not the specific pathway activated by contact with glass.
**Clinical Pearl / High-Yield Fact**
Remember that the intrinsic coagulation pathway is activated by contact with non-endothelial surfaces, such as glass or plastic, which can lead to the formation of thrombi and clotting disorders.
**Correct Answer:** C. Common pathway