A 15-year-old female presented to the emergency depament with history of recurrent epistaxis, Hematuria and hematochezia. There was a history of profuse bleeding from the umbilicus stump at bih. Previous investigations revealed normal prothrombin time, activated paial thromboplastin time, thrombin time and fibrinogen levels. Her platelet counts as well as platelet function tests were normal but urea clot lysis test was positive. Which one of the following clotting factor is most likely to be deficient?
A 15-year-old female presented to the emergency depament with history of recurrent epistaxis, Hematuria and hematochezia. There was a history of profuse bleeding from the umbilicus stump at bih. Previous investigations revealed normal prothrombin time, activated paial thromboplastin time, thrombin time and fibrinogen levels. Her platelet counts as well as platelet function tests were normal but urea clot lysis test was positive. Which one of the following clotting factor is most likely to be deficient?
π‘ Explanation
**Core Concept**
The patient's symptoms suggest a bleeding disorder characterized by spontaneous bleeding from multiple sites, including mucocutaneous and gastrointestinal sites, with normal coagulation tests and platelet function. This presentation is consistent with a deficiency of a specific clotting factor involved in the fibrinolysis pathway.
**Why the Correct Answer is Right**
The patient's positive urea clot lysis test indicates an abnormality in the fibrinolysis pathway, where fibrin clots are broken down too quickly. This is consistent with a deficiency of plasminogen activator inhibitor-1 (PAI-1), which normally inhibits the breakdown of fibrin clots. However, the correct answer is related to the deficiency of a clotting factor involved in the initial formation of the clot, which is then followed by excessive breakdown. The correct answer is related to the deficiency of a clotting factor involved in the initial formation of the clot.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not relevant to the patient's presentation.
* **Option B:** This option is not related to the fibrinolysis pathway or the patient's symptoms.
* **Option C:** This option is a platelet function test, which is normal in this patient.
**Clinical Pearl / High-Yield Fact**
Remember that bleeding disorders can present with normal coagulation tests and platelet function, requiring a high index of suspicion for disorders like fibrinolysis defects.
**Correct Answer:** D. Factor XIII.
β Correct Answer: D. Factor XIII
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