Action of ‘Telomerase’ is
**Core Concept**
Telomerase is an enzyme that plays a crucial role in maintaining the integrity of telomeres, the protective caps at the ends of chromosomes. Telomeres shorten with each cell division, leading to cellular aging and eventual cell death. Telomerase helps to counteract this process by adding nucleotides to the ends of chromosomes, effectively lengthening them.
**Why the Correct Answer is Right**
Telomerase works by adding nucleotides to the 3' end of telomeres through its reverse transcriptase activity. This process involves the addition of TTAGGG repeats to the telomeres, which helps to maintain their stability and prevent chromosomal fusion. Telomerase is particularly active in stem cells and cancer cells, where it helps to promote cellular immortality.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because telomerase is not involved in DNA repair, which is a separate process that involves the repair of damaged DNA strands.
**Option B:** This option is incorrect because telomerase is not a type of DNA polymerase, although it does share some similarities with them.
**Option C:** This option is incorrect because telomerase is not involved in the replication of viral genomes, although it does have some similarities with viral reverse transcriptases.
**Clinical Pearl / High-Yield Fact**
Telomerase activity is often used as a biomarker for cancer diagnosis, as many cancer cells exhibit elevated levels of telomerase activity. This can be exploited in cancer therapy, such as through the use of telomerase inhibitors to selectively target cancer cells.
**Correct Answer: C. Telomerase is an enzyme that elongates telomeres by adding nucleotides to the 3' end through its reverse transcriptase activity.**