Angioid streaks is seen in -a) Pseudoxanthoma Elasticumb) Acromegalyc) Paget’s diseased) All of above

## **Core Concept**
Angioid streaks refer to breaks or defects in the elastic lamina of the Bruch's membrane in the eye. This condition can lead to choroidal neovascularization and vision loss. It is often associated with systemic diseases that affect elastic tissue.

## **Why the Correct Answer is Right**
The correct answer involves identifying conditions associated with angioid streaks. Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by the degeneration of elastic tissue, particularly affecting the skin, retina, and cardiovascular system. It is a classic cause of angioid streaks due to its direct impact on elastic fibers. Acromegaly and Paget's disease can also affect various tissues but are less directly linked to the specific pathophysiology of angioid streaks compared to PXE.

## **Why Each Wrong Option is Incorrect**
- **Option B: Acromegaly** is incorrect because, while it involves abnormal growth and can affect multiple systems, it is not commonly associated with angioid streaks. Acromegaly primarily results from excess growth hormone.
- **Option C: Paget's disease** is incorrect as it primarily affects bone, leading to deformities and potential complications like osteosarcoma, but it is not typically associated with angioid streaks.
- **Option D: All of above** is incorrect because, although PXE is correctly associated with angioid streaks, not all listed conditions are equally or directly linked to this ocular manifestation.

## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that pseudoxanthoma elasticum (PXE) is a significant cause of angioid streaks, and patients with PXE often present with characteristic skin lesions and angioid streaks on fundoscopic examination. Recognizing PXE as a systemic condition can lead to early diagnosis and management of ocular and systemic complications.

## **Correct Answer: A. Pseudoxanthoma Elasticum**