**Core Concept**
Acro-osteolysis refers to the resorption or destruction of the distal phalanges and occasionally the terminal tufts of the fingers and toes. It is a rare condition that can be caused by various factors, including trauma, systemic diseases, or exposure to certain chemicals.

**Why the Correct Answer is Right**
The correct answer is associated with Bismuth subsalicylate, a medication commonly used for treating gastrointestinal issues such as heartburn and indigestion. Acro-osteolysis is a known side effect of long-term use or high doses of bismuth subsalicylate, leading to the destruction of the distal phalanges.

**Why Each Wrong Option is Incorrect**
* **Option A:** is not associated with acro-osteolysis.
* **Option C:** is not a known cause of this condition.
* **Option D:** is not a relevant factor in acro-osteolysis.

**Clinical Pearl / High-Yield Fact**
Bismuth subsalicylate can cause other systemic side effects, including black tongue, and can interact with certain medications, such as warfarin.

**Correct Answer:** B. Bismuth subsalicylate.