A 40 yr. old patient is presented with tumour like lesions on arms, legs buttocks and histology showed hyaline acidophilic inclusion bodies. Diagnosis is
## **Core Concept**
The question describes a patient with tumor-like lesions on the arms, legs, and buttocks, with histology showing hyaline acidophilic inclusion bodies. This presentation suggests a viral etiology, particularly one that causes cellular changes leading to the formation of inclusion bodies.
## **Why the Correct Answer is Right**
Molluscum contagiosum is a viral infection caused by the molluscum contagiosum virus (MCV), which belongs to the poxvirus family. It presents as multiple, small, dome-shaped, pearly, or flesh-colored papules or nodules with a characteristic central depression or dimple. Histologically, molluscum contagiosum is characterized by the presence of **hyaline acidophilic inclusion bodies**, also known as Henderson-Patterson bodies, within the cytoplasm of infected cells. These inclusion bodies are a hallmark of the disease and are diagnostic.
## **Why Each Wrong Option is Incorrect**
- **Option A:** While certain types of skin cancers and conditions can present with lesions, they do not typically show hyaline acidophilic inclusion bodies on histology.
- **Option B:** This option is not specified, but generally, other viral infections may cause skin lesions, they are less likely to present with the specific histological feature of hyaline acidophilic inclusion bodies.
- **Option C:** This option is not provided, but similar to option A, without specific details, it's hard to directly refute, but conditions not associated with inclusion bodies can be considered incorrect based on the provided histological findings.
## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that molluscum contagiosum is highly contagious and can spread through direct skin-to-skin contact or through fomites. The presence of **hyaline acidophilic inclusion bodies** on histology is diagnostic. A classic presentation is in children and young adults, but it can occur at any age.
## **Correct Answer:** D. Molluscum contagiosum.