ACE Inhibitors can cause all except
**Core Concept**
ACE inhibitors are a class of medications used to treat hypertension and heart failure by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to vasodilation, decreased peripheral resistance, and reduced blood pressure. ACE inhibitors also have a protective effect on the kidneys by reducing intraglomerular pressure.
**Why the Correct Answer is Right**
ACE inhibitors can cause a dry cough in some patients due to the accumulation of bradykinin, a potent vasodilator that is also involved in the cough reflex. This is because ACE is also responsible for breaking down bradykinin, and by inhibiting ACE, the levels of bradykinin increase. Additionally, ACE inhibitors can cause hypotension, especially in patients with heart failure or those taking other medications that lower blood pressure. They can also cause hyperkalemia, particularly in patients with kidney disease or those taking other medications that affect potassium levels.
**Why Each Wrong Option is Incorrect**
**Option A:**
- Not a known side effect of ACE inhibitors. ACE inhibitors can cause a dry cough, but not a sore throat.
**Option B:**
- Incorrect, ACE inhibitors can cause hyperkalemia due to reduced potassium excretion by the kidneys.
**Option C:**
- Incorrect, ACE inhibitors can cause hypotension, especially in patients with heart failure or those taking other medications that lower blood pressure.
**Clinical Pearl / High-Yield Fact**
When prescribing ACE inhibitors, it is essential to monitor renal function and potassium levels, especially in patients with kidney disease or those taking other medications that affect potassium levels.
**Correct Answer: A.**