ACE inhibitors are contraindicated in bilateral renal aery stenosis, because –
Correct Answer: Angiotensin II has direct effect on GFR
Description: Ans. is 'a' i.e., Angiotensin II has direct effect on GFR o Patients with renal aery stenosis are dependent on efferent aeriolar vasoconstiction for maintenance of glomerular filtration pressure. Angiotensin II is responsible for vasoconstriction of efferent aeriole. o ACE inhibitors prevent the generation of Angiotensin II. This causes dilatation of efferent aerioles and fall in glomerular filtration pressure. This can ppt renal failure. o Therefore ACE inhibition are C/I in patients with bilateral renal aery stenosis.
Category:
Pharmacology
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