In a patient with acute arsenic poisoning, which of these would show accumulation of As
**Core Concept**
In acute arsenic poisoning, the body's ability to eliminate arsenic is impaired, leading to its accumulation in various tissues. Arsenic is a potent toxin that can cause multi-organ failure if not promptly treated.
**Why the Correct Answer is Right**
Arsenic is primarily excreted by the kidneys, and its elimination is facilitated by the enzyme glutathione S-transferase (GST) and other cellular mechanisms. However, in cases of acute poisoning, the body's stores of glutathione are depleted, leading to impaired arsenic detoxification. As a result, arsenic accumulates in tissues such as the liver, kidneys, and blood.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not specify a tissue or organ where arsenic would accumulate. While arsenic does affect multiple systems, this option is too vague to be correct.
**Option B:** This option is incorrect because it suggests a tissue or organ where arsenic would not accumulate. The pancreas is not a primary site of arsenic accumulation in acute poisoning.
**Clinical Pearl / High-Yield Fact**
In cases of acute arsenic poisoning, prompt administration of succimer (a chelating agent) can help reduce arsenic accumulation and improve patient outcomes.
**Correct Answer:** C. Blood