According to myogenic hypothesis of renal autoregulation, the afferent arterioles contract in response to stretch induced by
Correct Answer: Opening of Ca2+ channels
Description: Stretch on smooth muscle (afferent arterioles) opens Ca+ channel, which causes contraction of afferent arterioles.the medullary interstitium.
REGULATION OF GFR
Regulation is done by:
Blood pressure: Autoregulation
Resistance of afferent and efferent anterioles
- Autoregulation: Constant maintenance of renal blood flow or, GFR over the span of renal perfusion pressure (pressure in renal artery minus pressure in renal vein ) from 80 to about 170mm Hg
- Mechanism of autoregulation:
i) Myogenic mechanism- contraction or relaxation of anteriolar smooth muscle in response to changes in vascular pressures; mediated by Ca++
ii) Tubule glomerular feedback (TGF) mechanism-mediated by macula densa cells (described later)
Category:
Physiology
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