**Core Concept**
Lidocaine is a local anesthetic and antiarrhythmic medication that can cause systemic side effects when absorbed in high concentrations. The systemic absorption of lidocaine can lead to central nervous system (CNS) and cardiovascular effects.

**Why the Correct Answer is Right**
The CNS effects of lidocaine include sedation, dizziness, and seizures, which are a result of its ability to block sodium channels in the brain. The cardiovascular effects of lidocaine include hypotension, bradycardia, and cardiac arrest, which are a result of its ability to block sodium channels in the heart. **Option B**, peripheral vasodilation, is not a direct effect of lidocaine's systemic absorption. Lidocaine's systemic absorption primarily affects the CNS and cardiovascular system, rather than causing peripheral vasodilation, which is more characteristic of other vasodilator medications.

**Why Each Wrong Option is Incorrect**
* **Option A:** CNS effects such as sedation, dizziness, and seizures can occur as a result of systemic absorption of lidocaine. Lidocaine's ability to block sodium channels in the brain leads to these CNS effects.
* **Option C:** Cardiovascular effects such as hypotension, bradycardia, and cardiac arrest can occur as a result of systemic absorption of lidocaine. Lidocaine's ability to block sodium channels in the heart leads to these cardiovascular effects.

**Clinical Pearl / High-Yield Fact**
When administering local anesthetics like lidocaine, it's essential to monitor for signs of systemic absorption, such as CNS effects or cardiovascular instability. This can be achieved by carefully titrating the dose, monitoring vital signs, and being prepared to intervene with supportive care if needed.

**Correct Answer:** B. Peripheral vasodilation is not a direct effect of lidocaine's systemic absorption.